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#1 » by Jennysblog (β297) » October 29th, 2019, 3:22 pm

Researchers Device New Way to Prevent Herpes Infection
Two scientists are presently working on a new research that examines how the herpes virus develops at cellular level and what can be done to target and slow down or prevent the evolution of the virus.

According to the researchers, the new investigation proposes that the possibility of preventing herpes virus from spreading by studying herpes virus infection at cellular stage and how to slow down the infection progress.

The herpes simplex 1 virus is extremely contagious, has no cure, and is responsible for oral infections. Most people living with the virus are even unaware because it can be asymptomatic in some cases. The virus cannot treated or cured after a person gets it. It just remains inactive in the body. In some cases, herpes signs can go unnoticed, but, it can be painful in other cases. It is very possible to pass on or transfer the herpes virus to an uninfected person even with no noticeable signs and symptoms.
The authors of the new research are, Emanuel Wyler, Ph.D., and Vedran Franke, Ph.D., from the Berlin Institute for Medical Systems Biology, in Germany. The research was published in the journal Nature Communications.

Details of the Research

The team were able to cultivate a procedure that aided them in forecasting how an infection will progress in separate cells. For the study, the research team made use of a single-cell RNA sequencing, which is an innovative system that permits for genetic expressions to be fragmented at a granular level than bulk RNA sequencing.

They used the sequencing to examine 12,000 cells from human skin with herpes simplex virus 1 (HSV1) infection. The scientists used the likeness of a smoothie to describe the dissimilarity between single cell RNA sequencing and orthodox, bulk RNA sequencing.

According to Wyler, if ten different fruits are placed in a blender and grinded, he can taste to tell which smoothie contains blackberries. Wyler added that with single-cell RNA sequencing, they are not making a smoothie but fruit salad. Meaning when compared to smoothie, it is quite easier to spot out different fruits in salad.

The scientists discovered that a transcription factor called NRF2, which was gotten after combining the technique with the algorithm. Transcription factors are proteins that can decipher information from our genome and activate or neutralize exact genes by binding to certain DNA areas. The activation of this NRF2 factor prevented the development of the herpes virus.

According to Franke, the new technique showed the importance of the NRF2 transcription factor. This is because after examining the changes in the control of each gene in a single cell, the NRF2 transcription factor can be an indicator for temporary resistance to HSV1 infection.”

The team learnt that two NRF2 activators, called bardoxolone methyl and sulforaphane harm the production of the herpes virus, making it activate fewer of its genes. This showed the importance of the role of NRF2.

The study showed that the stage of the cell cycle reveals how susceptible a cell is to HSV1 infection.

Conclusively, the scientists clarified that the herpes virus can be a helpful plan for examining cell states in viral infections.

Source: ... nfections/
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#2 » by eMade (f) VIP (β45726) » October 29th, 2019, 9:58 pm

:mrgreen: Nice to know.
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